In
Samaritan's quest to find an accurate diagnostic, inventors
have surprisingly found that central nervous system
DHEA is increased in patients having Alzheimer's, in
contrast to decreased levels of DHEA found in the periphery
(blood). Although this finding agrees with previous
reports that DHEA levels in Alzheimer's patients are
abnormally low and have been recommending taking DHEA
supplements as a means of prevention, it suggests that
brain DHEA formation is separate from peripheral DHEA
levels, thus questioning the use of DHEA as a means
of Alzheimer's disease prevention.
Samaritan
inventors have identified a distinct mechanism for
DHEA formation in brain from precursors that they
are able to follow in the blood; using a chemical
reaction, that allows the prediction of DHEA levels
in brain. This research has been the basis of Samaritan's
Alzheimer's diagnostic test and granting of research
funds from the National Institute of Health (NIH).
Samaritan
Pharmaceuticals has a simple blood test that is believed
to detect early damage resulting from Alzheimer's.
Currently, there are no diagnostic kits on the market
for the detection of neurodegenerative diseases such
as Alzheimer's disease at the present time. The disadvantage
in treating neurodegenerative diseases is the inablility
to determine the onset of the disease. With 360,000
new Alzheimer's cases reported each year in the U.S.,
this diagnostic kit will benefit every individual
over 55 years and older through a simple method of
detecting the increase of DHEA in blood serum.
Journals:
Neuropharmacology
2005; in press
Pharmacology 2005; 74:65-78
Neurobiology of Aging, 2003, 24-1:57-65
Journal of Neurochemistry, 2002,83:1110-1119
Steroids, 2004 Jan; 69(1):1-16