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 Dosage
and Administration:
Dosage:
Therapy
may begin at a daily dose of 1.0 mg/kg of body weight, increasing
to the recommended dose of 3.0-4.0 mg/kg as required. Doses as high
as 6 mg/kg have been used in patients. Dosage should be adjusted
to the individual requirements of each patient. The median cumulative
dose in clinical studies was 3.5 g and the median treatment duration
was 16 days. Ten percent (10%) of patients received 13 g or more
of Amphocil over a period of 27 to 409 days.
Administration:
Amphocil is administered
by intravenous infusion at a rate of 1 to 2 mg/kg/hour. If the patient
experiences acute reactions or cannot tolerate the infusion volume,
the infusion time may be extended. Pre-medication (e.g. paracetamol,
antihistamines, antiemetics) may be administered to patients who
have previously suffered infusion related adverse reactions.
Paediatric
Patients:
A limited number
of paediatric patients have been treated with Amphocil at daily
doses (mg/kg) similar to those in adults. No unusual adverse events
were reported.
Elderly
Patients:
A limited number
of elderly patients have been treated with Amphocil; available data
do not indicate the need for specific dose recommendations or precautions
in elderly patients.
Pictured
above right: Aspergillosis - GMS stained
lung of patient with Aspergillus fumigatus . (Click
Here for More Information)
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