Dr. Ewa K. Carrier M.D.
Member

EDUCATION:

11/96 Board Certified, Pediatric Hematology-Oncology.
12/92 Board Certified, American Board of Pediatrics.
11/89 Licensed, (#A047844) to practice in the State of California.
11/89 Physician and Surgeon oral examination for the State of California.
06/87 Flex Part (I (score 83) and Part II (score 83).
06/86 ECFMG certificate # 397-208-0.
07/85 FMGEMS.
09/76-09/82 M.D. Degree, Wroclaw University School of Medicine, Wroclaw, Poland.

CLINICAL EXPERIENCE/TRAINING:

07/04-present Associate Professor of Clinical Medicine and Pediatrics. University of California, San Diego, Department of Blood & Marrow Transplant Program, San Diego, CA.
01/98-6/04 Assistant Professor of Medicine and Pediatrics. University of California, San Diego, Department of Blood & Marrow Transplant Program, San Diego, CA.
07/97-12/97 Assistant Clinical Professor of Pediatrics. University of California, San Francisco, Division of Pediatric Bone Marrow Transplant, San Francisco, CA.
07/91-06/97 Postdoctoral Fellowship. University of California, San Francisco, Pediatric Bone Marrow Transplant, San Francisco, CA.
07/91-06/94 Hematology-Oncology Fellowship. Children's Hospital, Oakland, CA.
07/90-06/91 Pediatric Residency. Stanford University Medical Center, Stanford, CA.
07/88-06/90 Pediatric Residency. White Memorial Medical Center, Loma Linda University, Los Angeles, CA.
09/87 Medical Sub-internship. Stanford University Medical School, Internal Medicine Department. Stanford, CA.
07/83-07/84 Residency in Neurology. General Hospital, Jelenia Gora, Poland.
09/82-09/83 Rotating Internship. General Hospital, Jelenia Gora, Poland.

RESEARCH INTERESTS:

Embryonic stem cells
Stem cell biology/cellular therapy
Regenerative medicine
Tolerance/immunity following transplantation
Stem cell transplant for autoimmune diseases
Allogeneic transplants with reduced toxicity

PAPERS AND PUBLICATIONS:

1. Horning, S, Carrier, E, Rouse, R, Warnke, R, Michie, S. Lymphomas presenting as histologically unclassified neoplasms: Characteristics and response to treatment. J Clin Oncol 7(9): 1281-1287, 1989.

2. Carrier, E, Lee, TH, Busch, M and Cowan, MJ. Induction of tolerance in non-defective mice after in utero transplantation of major histocompatibility complex-mismatched fetal hematopoietic stem cells. Blood 86(12): 4681-4690, 1995.

3. Carrier, E, Lee, TH, Busch, M and Cowan, MJ. Recruitment of engrafted donor cells postnatally into the blood with cytokines after in utero transplantation in mice. Transplantation 64(4): 627-633, 1997.

4. Carrier, E. In Utero Transplantation. Textbook "Hematopoietic Stem Cell Therapy, Eds. Ball ED, Lister J and Law P. W.B. Saunders Publishing Company, Philadelphia, PA, 2000, Chap. 19, pp. 217-224.

5. Carrier, E. Murine Model of In Utero Transplantation. Eds. Ho AD, Marcel and Dekker Publishers, Inc., New York, NY, pp. 195-222, 2000.

6. Carrier, E. In Utero Transplantation. Gaucher, Clinical Perspectives Molecular Medicine & Therapeutics 8(1) (Issn 1079-2058): 6-11, 2000.

7. Burt RK, Brenner M, Burns W, Carrier E, Firestein G, Hahn B, Heslop H, Link C, McFarland H, Roland M, Territo M, Tsokos G, Traynor A. Gene-marked autologous hematopoietic stem cell transplantation of autoimmune disease. J Clin Immunol 20(1): 1-9, 2000.

8. Carrier E, Gilpin E, Lee TH, Busch MP, Zanetti M. Microchimerism does not induce tolerance post in utero transplantation and may lead to the development of alloreactivity. J Lab Clin Med 136(3): 224-235, 2000.

9. Bashey A, Corringham S, Gilpin E, DeFrancisco C, Santos-Ada O, Holman P, Carrier E, Lane TA, Ball ED, Law P. Simultaneous administration of G-CSF and GM-CSF for re-mobilization in patients with inadequate initial progenitor cell collections for autologous transplantation. Cytotherapy 2(3): 195-200, 2000.

10. Carrier E, Burt R. Stem cell transplantation for autoimmune diseases: pros and cons. Current Opinion in Organ Transplantation 5: 343-351, 2000.

11. Donahue J, Gilpin B, Lee, T.H., Busch, M.P., Croft, M., and Carrier E. Microchimerism does not induce tolerance and sustains immunity after in utero transplantation. Transplantation, Vol 71(3) 359-368 February, 2001.

12. Donahue J, Gilpin E, Young D. and Carrier, E. Postnatal cytokines and boosts improve chimerism and hematological parameters in b-thalassemic mice transplanted in utero. Transplantation, Vol 71:10 1491-1494, May 2001.

13. Voltarelli JC, Ahmed H, Paton E, Stracieri AB, Holman P, Bashey A, Coutinho M, Simoes BP, Ball ED, and Carrier E. Beneficial effect of intravenous lidocaine in cutaneous chronic graft-versus-host disease secondary to donor lymphocyte infusion. Bone Marrow Transplant 28(1): 97-99, 2001.

14. Donahue J, Carrier E. Non-myeloablative transplants for congenital diseases. Cancer Treat Res. 2002; 110: 177-211. Review.

15. Francis, K., Palsson, B., Donahue, J., Fong, S., Carrier, E. Murine Sca-1+/Lin- cells and human KG1a cells exhibit multiple pseudopod morphologies during migration. Exp. Hematol. 30: 460-463, 2002.

16. Sefrioui H, Donahue J, Gilpin EA, Srivastava AS, Carrier E. Tolerance and immunity following in utero transplantation of allogeneic fetal liver cells: the cytokine shift. Cell Transplant. 2003; 12 (1): 75-82. 17. Sefrioui H, Donahue J, Srivastava AS, Gilpin E, Lee TH, Carrier E. Alloreactivity following in utero transplantation of cytokine-stimulated hematopoietic stem cells: the role of recipient CD4(-) cells. Exp Hematol. 2002 Jun; 30(6): 617-24.

18. Donahue J, Carrier E. Non-myeloablative transplants for congenital diseases. Non Myeloablative Allogeneic Transplantation. Editors A. Bashey and E. Ball. Kluwer Academic Publishers 2002, 177-211

19. Tanner M.L., Hoh C.K., Bashey, A., Holman, P., Sun, C., Broome, H.E., Lane, T.A., Ball, E.D., Carrier, E.: FLAG chemotherapy followed by allogeneic stem cell transplant using nonmyeloablative conditioning induces regression of myelofibrosis with myeloid metaplasia. Bone Marrow Transplant 2003, 32(6): 581-85.

20. Srivastava A, Carrier E,. Immunological factors that affect, the in vivo fate of T7 phage in the mouse, J Virol Methods, 2004 Jan; 115(1): 99-104.

21. Carrier, E, Heiju Ledingham: 100 Questions and Answers about Bone Marrow and Stem Cell Transplantation. Jones & Bartlett Publishers, Incorporated. July 2003.

22. Carrier, E. and Richard Burt. Mobilization and conditioning regimens in stem cell transplant for autoimmune diseases. Landes Bioscience. Book chapter in book edited by Burt and Marmont:" Stem cell transplant for autoimmune diseases". 23. Srivastava AS, Oohara I, Suzuki T, Shenouda S, Singh SN, Chauhan DP, Carrier E. Purification and properties of cytosolic alanine aminotransferase from the liver of two freshwater fish, Clarias batrachus and Labeo rohita. Comp Biochem Physiol B Biochem Mol Biol. 2004 Feb; 137(2): 197-207.

24. Wang EH, Chen YA, Bashey A, Holman P, Ball ED, Carrier E. High-dose CEB vs. BEAM with autologous stem cell transplant in lymphoma. Bone Marrow Transplant, 2004 Oct, 34(7): 581-7.

25. Srivastava A, Chauhan, DP, Carrier, E, In utero detection of T7 phage after systemic administration to pregnant mice. BioTechniques, Vol. 37, No. 1, July 2004.

26. Lane TA, Bashey A, Carrier E. Holman P, Castro J, Mullen M, Ward DM, Ada O, and Ball ED. Improving the efficiency of PBPC collection by pre-apheresis peripheral blood and mid-apheresis product measurements of CD34 cells. Cytotherapy, 2004, 6(4): 318-327.

27. Burt, RK., Marmont, A., Arnold, R., Heipe, F., Firestein, GS., Carrier, E. , Hahn, B., Barr, W., Oyama,Y., Snowden, J., Kalunian, K., Traynor, A.: Development of a phase III trial of hematopoietic stem cell transplantation for systemic lupus erythematosus. Bone Marrow Transplant (2003) 32, 49-51.

28. Feng Z, Carrier E. A Regulatory Role of Wnt Signaling Pathway in the Hematopoietic Differentiation of Murine Embryonic Stem Cells. Biochem Biophys Res Commun. 2004 Nov 26; 324(4): 1333-9.

29. Moustafa M, Srivastava A, Nedelcu E, Donahue J, Gueorguieva I, Shenouda S, Minev B, and Carrier E., Chimerism and tolerance post in utero transplantation with ontogenically different sources of stem cells. Transplantation. 2004 Nov 15; 78(9): 1274-82.

30. Ball, E.D., Bashey, A., Carrier, E. Castro, J.E., Holman, P. and Lane, T.: Current Status of Bone Marrow Transplantation for Treatment of Cancer. IN Cancer Growth and Progression, 2nd Edition, Vol. 10, Cancer Management in Man: Biological Response Modifiers, Chemotherapy, Antibiotics, Hyperthermia, Supporting Measures Neoplastic Prevention. [Volume Editor: Minev, B., Series Editor: Kaiser, H.E.] (in press).

31. Chauhan, DP., Srivastava, AS., Moustafa, ME, Shenouda, S., Carrier, E. In Utero Gene Therapy: Prospect and Future. Curr Pharm Des., 2004, 10(29); 3663-72.

32. Lane, TA., Bashey, A., Carrier, E., Holman, P., Castro, J., Mullen, M., Ward, DM, Ada, O., Ball, ED.: Improving the efficiency of PBPC collection by pre-apheresis peripheral blood and mid-apheresis product measurements of CD34 cells. Cytotherapy (2004) Vol 6, No. 4, 318-327.

33. Kamrava MR, Anderson EM, Kalunian K, Bashey A, Holman P, Medina B, Ball ED, Carrier E. T-cell depletion improves outcome after autologous stem cell transplant in patients with systemic lupus erythematosus (SLE). Bone Marrow Transplant. 2005 Feb; 35(3): 321.

34. Richard K Burt, Bruce Cohen, Yu Oyama, Susan Stefoski, George Katsamakis, Ewa Carrier, George Ellison, Tomas Kozak, John Rose, Joel McGuirk, Paolo Muraro, Roger Hintzen, Shimon Slavin,Shalom Haggiag, Julio Voltarelli, Borko Jovanovic, Judith Haas, Renate Arnold. Hematopoietic Stem Cell Transplantation for Multiple Sclerosis. Archives of Neurology (in press)

ABSTRACTS:

1. Carrier, E, Lee, TH, Busch, M and Cowan, MJ. In utero engraftment of allogeneic mismatched murine fetal liver cells in fetal mice. Blood 82:299a, 1993.

2. Carrier, E, Lee, TH, Busch, M and Cowan, MJ. In utero transplantation of allogeneic fetal liver cells and tolerance induction in a mouse model. Blood 84(10): 497a, 1994.

3. Carrier, E, Lee, TH, Busch, M and Cowan, MJ. In utero engraftment of allogeneic bone marrow in non-defective mice-effects of postnatal injections of stem cell factor and G-CSF. Blood 86(10): 114a, 1995.

4. Carrier, E, Lee, TH, Busch, M and Cowan, MJ. Engraftment and tolerance induction following in utero transplantation of C-KIT+ cells in a mouse model. Blood 90(10): 312b, 1997.

5. Carrier, E, Lee, TH, Busch, M and Cowan, MJ. Tolerance induction following in utero transplant as tested by postnatal donor transplant. Blood 90(10): 363a, 1997.

6. Carrier, E, Lee, TH, Busch, M, Cowan, MJ, and Ho, AD. Engraftment and tolerance induction following in utero transplant with purified sources of stem cells. J Hematother 7(3): 269, 1998.

7. Donahue J, Lee TH, Busch M, Carrier E. Tolerance induction following in utero transplantation. 6th International Symposium on Recent Advances in Hematopoietic Stem Cell Transplantation, San Diego, CA April 1998

8. Carrier E. Engraftment and tolerance induction following in utero transplantation of C-kit+ cells in a mouse model. 6th International Symposium on Recent Advances in Hematopoietic Stem Cell Transplantation, San Diego, CA April 1998, pp. 33

9. Donahue J, Kuypers F, Witkowska E, Cowan M, Carrier E. Engraftment and tolerance following in utero transplantation in b-thalassemic mice. Blood 92(10) (Suppl 1): 286b (4232), 1998.

10. Donahue J, Lee TM, Busch M, Cowan M, Carrier E. Tolerance following in utero transplantation with c-kit+ cells. Blood 92(10)(Suppl 1): 286b (4233), 1998.

11. Bashey A, Corringham S, Holman P, Carrier E, Ward D, Ho AD, Lane TA, Law P. Second mobilization in patients with inadequate peripheral blood progenitor cell collections: The role of hematopoietic growth factor combinations. Blood 92(10)(Suppl 1): 97b (4280), 1998.

12. Holman PR, Bashey A, Kormanik P, Hougham NM, Carrier E, Ball E. Non-myeloablative stem cell transplantation in combination with Rituximab may be an effective strategy for the treatment of refractory chronic lymphocytic leukemia. 7th International Symposium on Recent Advances in Hematopoietic Stem Cell Transplantation, San Diego, CA, May 6-8, 1999.

13. Donahue J, Lee TH, Busch MP, Gilpin E, Carrier E. Evidence of immunity following in utero transplantation with c-kit positive. 7th International Symposium on Recent Advances in Hematopoietic Stem Cell Transplantation, San Diego, CA, May 6-8, 1999.

14. Law P, Bashey A, Ball ED, Ho AD, Holman P, Carrier E, Mullen M, Carlos R, Ada O Young DJ, Lane TA. Collection of allogeneic peripheral blood progenitor cell (Allo PBPC): comparison of good and bad mobilizers. Blood 94(10):137a, 1999.

15. Donahue J, Lee TM, Busch M, Carrier E. Microchimerism sustains active postnatal immunity in mice primed in utero with allogeneic cells. Blood 94(10): 318a, 1999.

16. Bashey A, Corringham S, Fields KF, Holman P, Carrier E, Lane TA, Ball ED, Smilee RC, Janseen WE, Law P. Use of concurrent GM-CSF and G-CSF administration to re-mobilize patients who fail initial mobilization: results on twenty-three patients from two centers. Blood 94(10): 327a, 1999.

17. Bashey A, Corringham S, Gilpin E, Holman P, Carrier E, Lane TA, Ball ED, Law P. Efficient and predictable mobilization of peripheral blood progenitor cells (PRPC) using an intermediate dose of cyclophosphamide (Cy) followed by sequential GM-CSF and G-CSF. Blood 94(10):329a, 1999.

18. Holman PR, Bashey A, Corringham SM, Carrier E, Quigley JO, Ball ED. High dose Topotecan plus Melphalan: a safe and tolerable preparative regimen for autologous transplantation in multiple myeloma. Blood 94(10):578a, 1999.

19. Donahue J, Gilpin E, Lee TM, Busch M, Zanetti M, Carrier E. Lack of tolerance and evidence of immunity following in utero transplantation with c-kit positive cells. Blood 94(10):663a, 1999.

20. Donahue J, Kuypers E, Witkowska E, Carrier E. Improvement in hematological parameters with low-level chimerism following in utero transplantation in a murine model of ?-thalassemia. Blood 94(10):664a, 1999.

21. Chen J, Bashey A, Holman P, Carrier E, Law P, Ball ED. A phase I dose escalating study of infusion of a bispecific antibody (BaAb) for relapsed/refractory acute myeloid leukemia (AML). Blood 94(10):227b, 1999.

22. Holman PR, Corringham S, Law P, Bashey A, Carrier E, Ball ED. Day 1 versus day +5 G-CSF administration following autologous stem cell transplantation. Blood 94(10): 357b, 1999.

23. Donahue J, Kuypers F, Witkowska E, Carrier E. Tolerance and improvement in hematological parameters following in utero transplantation in ?-thalassemic mice. 8th International Symposium on Recent Advances in Hematopoietic Stem Cell Transplantation, Heidelberg, Germany, May 4-6, 2000, pp. 242.

24. Donahue J, Lee TH, Busch M, Carrier E. Microchimerism sustains active postnatal immunity in mice primed in utero to allogeneic cells. 8th International Symposium on Recent Advances in Hematopoietic Stem Cell Transplantation, Heidelberg, Germany, May 4-6, 2000, pp. 259.

25. Donahue J, Kuypers F, Witkowska E, Carrier E. Improvement in hematological parameters following in utero transplantation in ?-thalassemic mice. ISHAGE 2000, San Diego, CA, June 15-18, 2000 Final Program.

26. Donahue J, Croft M, Lee TH, Busch M, Carrier E. Microchimerism sustains immunity to allogeneic cells post in utero transplantation. ISHAGE 2000, San Diego, CA, June 15-18, 2000 Final Program.

27. Law P, Bashey A, Ball ED, Ho AD, Holman P, Carrier E, Oblon D, Ward DM, Mullen M, Carlos R, Ada O and Lane TA. Leukapheresis collection of peripheral blood progenitor cells (PBPC) for allogeneic transplantation. 6th International Annual Meeting of International Society for Hematology and Graft Engineering, San Diego, CA. June 15-18, 2000.

28. Law P, Corringham S, Gilpin E, Fields KK, Smilee RC, Ada O, Holman P, Carrier E, Ho AD, Lane TA, Ball ED, Janssen WE, and Bashey A. Use of GM-CSF and G-CSF for re-mobilization of patients with inadequate initial peripheral blood progenitor cell (PBPC) collections for autologous transplantation. 6th International Annual Meeting of International Society for Hematology and Graft Engineering, San Diego, CA. June 15-18, 2000.

29. Francis K, Lee GM, Fong S, Donahue J, Carrier E and Palsson BO. The study of cellular fate processes in hematopoietic cells using an automated microscope system. Annual Meeting of Experimental Biology, San Diego, CA. April, 2000.

30. Francis K, Gemmen G, Lopez C, Carrier E and Palsson BO. Analysis of murine hematopoietic stem cell tracks in the context of a random walk model. Keystone Symposia, Keystone, Colorado. January, 2000.

31. Donahue J, Gilpin E, Young D, Carrier E. Cytokines and postnatal boosts improve hematological parameters following in utero transplantation in ??thalassemic mice. J Biol Blood & Marrow Transplant 2001; 7(2): 70 (Abstract 25).

32. Donahue J, Lee TH, Busch M, Gilpin E, Carrier E. Microchimerism sustains active postnatal immunity in mice primed in utero to allogeneic cells. J Biol Blood & Marrow Transplant 2001; 7(2): 70 (Abstract 26).

33. Francis K, Lee GM, Fong S, Donahue J, Carrier E and Palsson BO. The study of cellular fate processes in hematopoietic cells using an automated microscope system. Keystone Symposia, Lake Tahoe, CA. April, 2001.

34. Francis K, Lee GM, Fong S, Donahue J, Carrier E and Palsson BO. The study of cellular fate processes in hematopoietic cells using an automated microscope system. Annual Meeting of American Chemical Society 2001, San Diego, CA. April, 2001.

35. Srivastava AS, Tinkov F, Friedmann, Carrier E. Detection of T7 phage in the fetus after systemic administration to pregnant mice. Proc. 9th Annual International Symposium on Recent Advances in Hematopoietic Stem Cell Transplantation, San Diego, CA. March 29-31, 2001; pp. 230, Abstract (Poster).

36. Sefriouri H, Donahue J, Srivastava A, Carrier E. Tolerance following in utero transplantation of allogeneic hematopoietic stem cells. Proc. 9th Annual International Symposium on Recent Advances in Hematopoietic Stem Cell Transplantation, San Diego, CA. March 29-31, 2001; pp. 231, Abstract (Poster).

37. Pillai GR, Srivastava AS, Sefrioui H, Carrier E. Differential sensitivity of human lung cancer cell lines to curcumin. Proc. 9th Annual International Symposium on Recent Advances in Hematopoietic Stem Cell Transplantation, San Diego, CA. March 29-31, 2001; pp. 232, Abstract (Poster).

38. Francis K, Gemmen GJ, Lopez C, Carrier E, Pallson BO. Analysis of murine hematopoietic stem cell tracks in the context of a random walk model. Proc. 9th Annual International Symposium on Recent Advances in Hematopoietic Stem Cell Transplantation, San Diego, CA. March 29-31, 2001; pp. 235, Abstract (Poster).

39. Sefriouri, H., Donahue, J., Srivastava, A., Pillai, G.R., Young, D., and Carrier, E. Immunity without microchimerism after in utero transplantation of hematopoietic stem cells. Exp Hematol - ISEH 2001; Vol 28, 8, Supplement 1, August 2001, abstract 426 page 109.

40. Bashey, A., Corringham, S., Ji, M., Holman, P., Carrier, E., Oblon, D., Chen, J., Ball, E., Law, P. Analysis of the Efficiency and Predictability of PBPC Mobilization Using Intermediate Dose Cyclophosphamide Followed by Sequential GM-CSF and G-CSF in Sixty Patients Undergoing Autologous Transplantation. American Society of Hematology Annual Meeting, December 2001, Orlando, FL.

41. Holman, P., Joyce, R., Oblon, D., Bashey, A., Carrier, E., Chen, J., Vemuri, L., Corringham, S., Quigley, J., Ball, E. A Phase I/II Study of High Dose Topotecan (T) with Melphalan (M) Followed by Autologous Stem Cell Transplantation (ASCT) in Multiple Myeloma (MM) with Non-Hodgkin's Lymphoma (NHL). American Society of Hematology Annual Meeting, December 2001, Orlando, FL.

42. Hassane Sefrioui, Jody Donahue, Anand S. Srivastava, Tzong-Hae Lee, Michael P. Busch, Ewa Carrier. Immunity without Microchimerism after In Utero Transplantation of Hematopoietic Stem Cells. American Society of Hematology Annual Meeting, December 2001, Orlando, FL.

43. Karl Francis, Greg Gemmen, Bernhard Palsson, Ewa Carrier. Murine Sca-1+/Lin- Cells and the Human AML Cell Line KG1a, Exhibit Multiple Pseudopod Morphologies and Non-Markovian Movement during Locomotion. American Society of Hematology Annual Meeting, December 2001, Orlando, FL.

44. Anand S. Srivastava, Thomas J. Kaido, Ewa Carrier. Kinetics of T7 Phage Neutralization in the Blood of Normal and Immunodeficient Mice. American Society of Hematology Annual Meeting, December 2001, Orlando, FL.

45. Ewa Carrier. Chimerism and Tolerance Following In Utero Transplantation with Embryonic, Fetal and Adult Sources of Stem Cells. 2002 Tandem BMT Meeting, IBMTR, ABMT, ASBMT. Biology of Blood and Marrow Transplantation Vol 8 (2): 72.

46. Zhongling Feng, Ewa Carrier. In Vivo Differentiation of Embryonic Stem Cells, Blood 100(11): 4126, 2002

47. Zhongling Feng, Hamand Bayat, K. John Burhan, Anthony DeMaria, Ewa Carrier. Repair of Infarcted Heart by Embryonic Stem Cells. Blood 100(11); 127, 2002

48. Elena Nedelcu, Anand S. Srivastava, Nissi M. Varki, G. Assatourian, Ewa Carrier. Embryonic Stem Cells Survive and Proliferate after Intraperitoneal In Utero Transplantation and Produce Teratocarcinoma. Blood 100(11);4 129, 2002

49. Peter Holman, Asad Bashey, Ewa Carrier, Sue Corringham, Rui-kun Zhong, James Mason, Edward D. Ball. Phase I Dose Escalation Study of a Single Dose of Anti-CD33 x Humanized Murine Anti-FeyRi Bispecific Antibody in Patients and Relapsed Acute Myeloid Leukemia, Blood 100(11); 4606, 2002

50. Peter Holman, Asad Bashey, Ewa Carrier, Sue Corringham, Bridget Davis, David John Oblon, Jian Chen, Daniel Gold, Xi Mu, Edward D. Ball. Immune Response to Idiotype Vaccination Following High Dose Chemotherapy + Autologous Stem Cell Transplant in Indolent and Mantle Cell Lymphoma. Blood 100(11); 4803, 2002

51. Peter Holman, Asad Bashey, Ewa Carrier, Sue Corringham, Edward D. Ball. Autologous Stem Cell Transplant with and without Growth Factor Support in Patients Receiving > 5x106/kg CD34+ Cells: Engraftment and Infectious Outcomes, Blood 100(11); 5308, 2002

52. Asad Bashey, Kathy Witta, Jodi Garrett, Peter Holman, Ewa Carrier, Sue Corringham, Edward D. Ball, Karen Ballen, Robert Emmons, Peter Westervelt. Unrelated Donor Hematopoietic Cell Transplantation in Older Patients using a Non-Myeloablative Preparative Regimen: Universal Donor Cell Engraftment and Reduced Regimen-Related Toxicity. Blood 100(11); 5453, 2002

53. Anand S. Srivastava, Ewa Carrier. In Utero Targeting the Fetal Liver by Using T7 Phage Display System, Blood 100(11); 5541, 2002

54. Anand S. Srivastava, Ewa Carrier. Factor Responsible for In Vivo Neutralization of T7 Phage Display Vector in Blood of Mice. Blood 100(11); 5543, 2002

55. Wang EH, Chen YA, Bashey A, Holman P, Ball ED, Carrier E. High-dose CEB vs BEAM with autologous stem cell transplant in lymphoma. Biology of Blood and Marrow Transplantation. 2004 Tandem BMT meetings. 56. Feng, Z., Carrier, E.: " A role of Wnt signaling pathway in the hematopoietic differentiation of ES cells". J Exp Hematol, Vol 32, Number 7, Suppl. 1, July 2004.

57. Anand S Srivastava, Steve Shenouda, Ewa Carrier. Damaged murine brain induces ES cells into migration and differentiation. Blood, Volume 104, No 11, November 11, 2004.

58. Asad Bashey, Lin Liu, Ihasz Anita, Ewa Carrier, Januario Castro, Edward Ball, Thomas Lane. Effect of the administration of Rituximab between mobilization chemotherapy and leukopheresis on stem cell collection parameters: a study of fifty NHL patients mobilizied using intermiediate dose cyclophosphamide and sequential GM-CSF and G-CSF. Blood, Volume 104, No 11, November 11, 2004.

59. Thomas A. Lane, Asad Bashey, Ewa Carrier, Peter Holman, Edward D. Ball. Effect of graft content outcome of allogeneic marrow transplantation in acute leukemia. Blood, Volume 104, No 11, November 11, 2004.

60. Bashey A, Medina B, Zhong R-K, Zhou J-H, Carrier E et al. Phase I study of a neutralizing monoclonal anti-CTLA4 antibody (MDX-010) in patients with relapse of malignancy after allogeneic hematopietic stem cell transplantation. Biology of Blood and Marrow Transplantation. Volume 11, Number 2, Supplement 1, February 2005.

61. Feng Z, Arrunmategui-Correa V, Kim HS, Carrier E. Repair of Crohn's Disease with embryonic stem cells. Biology of Blood and Marrow Transplantation. Volume 11, Number 2, Supplement 1.

62. Shu F, Bashey A, Carrier E, Castro J, Holman P, Lane T, Ball ED. Consolidation and moblization of peripheral blood stem cells using high-dose cytarabine and etoposide in acute myeloid leukemia: a single institutional experience. Biology of Blood and Marrow Transplantation. Volume 11, Number 2, Supplement 1, February 2005.

INVITED PRESENTATIONS & PAPERS:

1. 6th International Symposium on Recent Advances in Hematopoietic Stem Cell Transplantation, San Diego, CA. 04/98. Tolerance induction following in utero transplantation.

2. Medical Grand Rounds. UCSD Department of Medicine. 04/98. In utero transplantation.

3. 4th Meeting of International Society for Hematotherapy and Graft Engineering, Baltimore, MD. 06/98. Engraftment and tolerance induction following in utero transplantation with purified sources of stem cells.

4. Advances in Stem Cell and Gene Therapy for Genetic Diseases. 09/98. Reno, Nevada. Tolerance following in utero transplantation with c-kit+ stem cells.

5. Tandem BMT Meetings, Keystone, CO. 03/4-6/99. Evidence of immunity following in utero transplantation with c-kit+ cells.

6. 7th International Symposium on Recent Advances in Hematopoietic Stem Cell Transplantation, San Diego, CA. 05/6-8/99. Evidence of immunity following in utero transplantation with c-kit+ cells.

7. 5th International Meeting of the Correction of Genetic Diseases by Transplantation (COGENT) Society, Minneapolis, MN. 06/18-20/99. In Utero Transplantation - Tolerance or Immunity?

8. 41st Annual Meeting of the American Society of Hematology (ASH), New Orleans, LA. 06/99. Lack of Tolerance and Evidence of Immunity Following In Utero Transplantation With C-Kit Positive Cells.

9. 41st Annual Meeting of the American Society of Hematology (ASH), New Orleans, LA. 06/99. Improvement in Hematological Parameters With Low-Level Chimerism Following In Utero Transplantation in a Murine Model of ß-Thalassemia.

10. Marrow Transplantation in Children: Current Results and Controversies. Hilton Head Island, SC. 12/00. Donahue J, Croft M., Lee TH, Busch M, Carrier E. Microchimerism Sustains Immunity to Allogeneic Cells Post In Utero Transplantation.

11. 8th International Symposium on Recent Advances in Hematopoietic Stem Cell Transplantation, Heidelberg, Germany. 6/00. Carrier E. Tolerance and improvement in hematological parameters following in utero transplantation in ß-thalassemic mice.

12. International Society for Hematotherapy and Graft Engineering, San Diego, CA. 06/15/00-6/18/00. Carrier E. Improvement in Hematological Parameters Following In Utero Transplantation in b-thalassemic Mice.

13. International Society for Hematotherapy and Graft Engineering, San Diego, CA. 06/15/00-6/18/00. Carrier E. Microchimerism Sustains Immunity to Allogeneic Cells Post In Utero Transplantation.

14. VI International Conference on In Utero Transplantation, Venice, Italy, 10/23-10/24, 2000. Carrier E. Improvement in hematological parameters following in utero transplantation in ?-thalassemic mice.

15. 9th International Symposium on Recent Advances in Hematopoietic Stem Cell Transplantation, San Diego, California. 03/29-31/01. In Utero transplantation as a model of post-transplantation tolerance/immunity.

16. American Society of Hematology 2000, San Francisco. (poster) Donahue J, Gilpin E, Lee T-H, Busch MP, Croft M, Carrier E. Microchimerism does not induce tolerance and sustains immunity after in utero transplantation.

17. International Society of Experimental Hematology, August 2001, Tokyo, Japan. Sefriouri, H., Donahue, J., Srivastava, A., Pillai, G.R., Young, D., and Carrier, E. Immunity without Micro-chimerism after In Utero Transplantation of Hematopoietic Stem Cells.

18. Fifth International Symposium on In Utero Stem Cell Transplantation and Gene Therapy, October, 2001, Reno, NV. Carrier, Ewa. Chimerism and Tolerance Following In Utero Transplantation with Embryonic, Fetal and Adult Sources of Stem Cells.

19. Tandem BMT meetings, IBMTR/AMBT, February, 2002. Orlando, FL. Carrier, Ewa: Chimerism and tolerance following in utero transplantation with embryonal, fetal and adult sources of stem cells.

20. Tenth International Symposium on Recent Advances in Hematopoietic Stem Cell Transplantation, Heidelberg, Germany, April 27-29, 2002. Carrier, Ewa: Chimerism and tolerance following in utero transplantation with embryonal, fetal and adult sources of stem cells.

21. 18th International Congress of Clinical Chemistry and Laboratory Medicine, Kyoto, Japan, October 20-25, 2002. Srivastava AS and Carrier E: Distribution and Stability of T7 phage in the mouse after intravenous administration.

22. American Society of Gene Therapy, Boston, MA, Srivastava AS, Kaido, T. and Carrier, E.: Immunological factors that affect the in vivo fate of T7 phage in the mouse.

23. American Society of Gene Therapy, Boston, MA, Srivastava AS, Nedelcu, E and Carrier E: Engraftment of murine embryonic stem cells after in utero transplantation.

24. American Assn. Of Immunologists (AAI) annual meeting, April 20-24, 2002, New Orleans, LA, Rizzi M, Kaido T, Gerloni M, Schuler K, Srivastava, AS, Carrier E and Zanetti M: Neonatal T cell immunity by in utero immunization.

25. The Science of Whole Person Healing Conference, March 28-30, 2003, Bethesda, MD, Zhongling Feng and Ewa Carrier: Cellular Therapy: A Future Medicine.

26. 11th International Symposium on Recent Advances in Stem Cell Transplantation, San Diego, CA May 8-10, 2003. Lane TA, Bashey A, Carrier E, Holman P, Ward D, Mullen M, Ada O, Ball E.: Utility of Mid-Run Apheresis CD34 Values in Managing Apheresis Collection of Mobilized Hematopoietic Progenitor Cells (HPC).

27. 11th International Symposium on Recent Advances in Stem Cell Transplantation, San Diego, CA May 8-10, 2003. Shenouda S, Srivastava A, Carrier E.: In vivo survival of Hematopoietic Stem cells in mouse brain.

28. 11th International Symposium on Recent Advances in Stem Cell Transplantation, San Diego, CA May 8-10, 2003. Srivastava A, Carrier E.: Distribution and Stability of T7 Phage in Mouse.

29. 11th International Symposium on Recent Advances in Stem Cell Transplantation, San Diego, CA May 8-10, 2003. Feng Z, Carrier E.: In vivo Differentiation of Embryonic Stem Cells

30. 11th International Symposium on Recent Advances in Stem Cell Transplantation, San Diego, CA May 8-10, 2003. Moustafa M, Srivastava A, Nedelcu E, El-Sadaani M, Minev B, Carrier E,: Chimerism and tolerance post in utero transplantation with ontogenically different sources of stem cells.

31. 32nd Annual Meeting of the International Society for Experimental Hematology, Paris, France July 5-8, 2003. Moustafa M, Srivastava A, Nedelcu E, El-Sadaani M, Minev B, Carrier E:

32. Chimerism and tolerance post in utero transplantation with ontogenically different sources of stem cells.

33. 32nd Annual Meeting of the International Society for Experimental Hematology, Paris, France, July 5-8, 2003. Feng Z, Carrier E.: In vivo Differentiation of Embryonic Stem Cells,

34. American Society for Blood and Marrow Transplantation, Orlando, Fl, February 13, 2004, Moustafa M, Srivastava A, Nedelcu E, El-Sadaani M, Minev B, Carrier E,: Chimerism and tolerance post in utero transplantation with ontogenically different sources of stem cells

35. American Society for Blood and Marrow Transplantation, Orlando, Fl, February 13, 2004. Wang, E., Chen, Y., Castro, J., Bashey, A., Holman, P., Corringham, S., Lane, T., Ball, E., Carrier, E, High-Dose CEB versus beam with autologous stem cell transplant in lymphoma.

36. 12th Annual International Symposium of Recent Advances in Stem Cell Transplantation, Heidelberg, Germany, April 22-24th, 2004, Zhongling, F., Carrier, E: A role of Wnt signaling pathway in the hematopoietic differentiation of murine embryonic stem cells,.

37. 45th Annual American Society of Hematology Meeting, San Diego, CA, December 6-9th, 2003, Lane, T., Bashey, A., Carrier, E., Holman, P., Mullen, M., Ball, E., Poster Presentation: Measurement of CD34 Cells on the Leukapheresis Product (LP) at the Mid Point of LP Versus on Peripheral Blood Prior to LP to predict the Amount of CD34 cells collected during LP

38. 45th Annual American Society of Hematology Meeting, San Diego, CA, December 6-9th, 2003, Bashey, A., Liu, L., Ji, M., Ihasz, A., Corrington, S., Holman, P., Carrier, E., Castro, J., O'Reilly, E., Law, P., Holman, Ball, E., Lane, T., Poster Presentation: Intermediate dose Cyclophosphamide followed by sequential GM-CSF and G-CSF Produces Efficient and Predictable PBPC Mobilization for Autografting: A single center study of one hundred and thirty-five patients.

39. 45th Annual American Society of Hematology Meeting, San Diego, CA, December 6-9th, 2003, Bashey, A., Liu, L., Lane, T., Ihasz, Bridget, M., A., Corringham, S., Carrier, E., Holman, P., Castro, J., Ball, E., Poster Presentation: Use of non-anthracyline savage regiment as induction therapy for untreated high-risk AML is effective and avoids the toxicity associated with sequential induction regimens.

39. 45th Annual American Society of Hematology Meeting, San Diego, CA, December 6-9th, 2003, Moustafa M, Srivastava A, Nedelcu E, Shenouda S, Minev B, Carrier E: Chimerism and tolerance after in utero transplantation of ES cells.

40. 45th Annual American Society of Hematology Meeting, San Diego, CA, December 6-9th, 2003, Holman, P., Medina, B., Corringham, S., Bashey, A., Carrier, E., Mu, X., Gold, D., Ball, E., Poster Presentation: Early and robust immune responses to idiotype (Id) Vaccination occur in mantle cell lymphoma (MCL) and Indolent Lymphoma (IL) Patients following autologous stem cell transplantation (ASTC) 41. 45th Annual American Society of Hematology Meeting, San Diego, CA, December 6-9th, 2003, Zhongling, F., Carrier, E: A role of Wnt signaling pathway in the hematopoietic differentiation of murine embryonic stem cells.

42. 45th Annual American Society of Hematology Meeting, San Diego, CA, December 6-9th, 2003, Wang, E., Chen, Y., Castro, J., Bashey, A., Holman, P., Corringham, S., Lane, T., Ball, E., Carrier, E, High-Dose CEB versus beam with autologous stem cell transplant in lymphoma.

43. (AACR) American Association for Cancer Research Annual Meeting, Orlando, Fl, Mar. 26-29 th, 2004. Zhongling, F., Carrier, E: A role of Wnt signaling pathway in the hematopoietic differentiation of murine embryonic stem cells 44. The American Society of Gene Therapy's 7th Annual Meeting, Minneapolis, MN, June 2004, Srivastava, A., Shenouda, S., Moustafa, M., Carrier, E., Increased expression of OCT4, SOX2, and FGF4 genes following injection of embryonic stem cell into damaged murine brain.

45. 2nd Annual Meeting of the International Society for Stem Research, Boston MA, June 10-13th, 2004, Feng, Z., Carrier, E. A Role of WNT Signaling pathway in the Hematopoietic Differentiation of Murine Embryonic Stem Cells.

46. 2nd Annual Meeting of the International Society for Stem Research, Boston MA, June 10-13th, 2004. Moustafa M, Srivastava A, Nedelcu E, El-Sadaani M, Minev B, Carrier E: Chimerism and tolerance post in utero transplantation with ontogenically different sources of stem cells.

47. 33rd Annual Meeting of the International Society for Experimental Hematology, New Orleans, LA, July 17-20,2004, Feng, Z., Carrier, E., A Role of WNT Signaling pathway in the Hematopoietic Differentiation of Murine Embryonic Stem Cells.

48. (AACR) American Association for Cancer Research Annual Meeting, Orlando, Fl, Mar. 26-29 th, 2004. Zhongling, F., Carrier, E: A role of Wnt signaling pathway in the hematopoietic differentiation of murine embryonic stem cells.

49. The American Society of Gene Therapy's 7th Annual Meeting, Minneapolis, MN, June 2004, Srivastava, A., Shenouda, S., Moustafa, M., Carrier, E., Increased expression of OCT4, SOX2, and FGF4 genes following injection of embryonic stem cell into damaged murine brain.

50. 2nd Annual Meeting of the International Society for Stem Research, Boston MA, June 10-13th, 2004, Feng, Z., Carrier, E. A Role of WNT Signaling pathway in the Hematopoietic Differentiation of Murine Embryonic Stem Cells.

51. 33rd Annual Meeting of the International Society for Experimental Hematology, New Orleans, LA, July 17-20,2004, Feng, Z., Carrier, E., A Role of WNT Signaling pathway in the Hematopoietic Differentiation of Murine Embryonic Stem Cells.

52. 2005 Tandem BMT meetings, February 10-14, 2005, Keystonne Colorado. Feng Z, Arrunmategui-Correa V, Kim HS, Carrier E. Repair of Crohn's Disease with embryonic stem cells.

53. 9th International Conference on Neural Transplantation and repair. Damaged murine brain induces ES cells into migration and proliferation. Taipei, Taiwan, June 2005. Travel award.

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TEACHING

Med 401 (elective outpatient clerkship for 3rd year medical students)
Med 454 (elective inpatient clerkship for 4th year medical students)
SOM 214 course (hematology course for 4th year medical students)
Med 260 course (teaching on modern techniques in biomedical research)
Heme/Onc rounds for pediatric residents PL-2 rounds for Pediatric residents Neonatal Hematology course (Children's Hospital)
OSCE clinical exam for 2nd year medical students
Faculty Mentor Program for undergraduate students
UCSD Howard Hughes teaching courses for undergraduate students
Postgraduate Researchers mentoring
Pediatric Residents launch teaching series (Children's Hospital)

UNIVERSITY/PUBLIC SERVICE

MSTP Program Admissions Subcommittee to RAC
Developed monthly BMT Educational Conferences
Developed Senior Elective Clerkship Med 454 for SOM
Initiated M/M Conferences at BMT division/Children's Hospital at UCSD
Assisted UCSD Health Science Communication in educating community on stem cells
Member of the Council of Healthcare Advisors
Member of the Medical Review of America
CCN Managed Care Specialty Advisor
NIH grant reviewer
Editor of a book aimed at educating the public on stem cells (Ewa Carrier, Heiju Ledingham: 100 Questions and Answers about Bone Marrow and Stem Cell Transplantation. Jones & Bartlett Publishers, Inc.)
UCSD MDTV-edited 2 programs aimed at educating community on stem cells
Introduced and helped to established Photophoresis Program at UCSD
Represented UCSD at meetings organized by Swedish Embassy/Nature on biotechnology
Expert witness-based on her t testimony the standard of care for prenatal diagnosis at Sharp/Health Care system was changed
Assisted International Council of San Diego and the US Department of the State's International Program
Gave series of lectures to Planned Parenthood Society, AWIS (Association of Women in Science) and Rancho Bernardo Community Educational Center.
NIH Working Group, Regenerative Medicine Roadmap Development 2003

REVIEWER IN PEER REVIEW JOURNALS

Blood Transplantation
Bone Marrow Transplantation
Haematologica
Experimental Hematology
Cell Transplantation

RESEARCH GRANTS:
Active/Awarded:

Broad Medical Research Program, 9/1/04-8/31/05, Repair of Crohn's Disease with Stem Cells, $110,000/yr; PI- Ewa Carrier

NIH/NIDDK R01 D57524-03 (09/15/99-2/28/05). Mixed Chimerism Following Prenatal Tolerance Induction. $225,000/yr; PI – Ewa Carrier

Ronald McDonald House Charities Medical Grant (07/01/98-01/31/05). Lentiviral Gene Transfer in ß-Thalassemic Mice. $118,490/yr.; PI – Ewa Carrier

NIH 5 K08 HL03602-04 (01/01/97-12/31/02). In utero transplantation of stem cell in ß-thalassemic mice. $102,750/year; PI – Ewa Carrier, Years – 5; Start Date – 01/01/97

Academic Senate Committee on Research Grant (05/99-06/00)

Academic Senate Committee on Research Grant (07/98-06/99)

Cooley's Anemia Foundation Research Grant (07/93-06/97). In utero transplantation in a mouse model. $50,000

McCormack Foundation Grant, Stanford University School of Medicine (07/86-06/87).
AWARDS:
America's Top Pediatricians, Consumer's Research Council of America, Washington, DC, 2004-2005

Graduated from the National Center of Leadership in Academic Medicine, University of California, San Diego. (05/99-11/99)

Molecular Biology Workshop sponsored by National Cancer Institute and American Association for Cancer Research, Aspen, CO, 1993

Received University Scientific Award yearly. Visiting Scholar in Medical Schools: Seged, Hungary, 1979; Florence, Italy, 1980; Manchester, England, UK, 1981

Received scholastic award yearly. Granted free admittance to all Polish and Slavic Universities and Medical Schools in 1976

Graduated with honors, 1982, Wroclaw University School of Medicine, Wroclaw, Poland

MEMBERSHIPS:
American Academy of Pediatrics.
American Medical Association.
American Society of Hematology.
American Society of Clinical Oncology.
American Society for Blood and Marrow Transplantation
International Society for Stem Cell Research

LANGUAGES:
English, French, Russian, Polish, Latin

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